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伪尾-Tubulin鐣颁簩鑱氶珨鏄井绠＄殑鏍稿績绲勬垚鍠厓锛岃€屽井绠″湪鐧岀窗(x矛)鑳炵殑鏈夌挡鍒嗚涓壆婕旇憲鑷抽棞(gu膩n)閲嶈鐨勮鑹�锛屽洜姝ゆ垚鐐虹檶鐧ュ寲鐧傜殑閲嶈闈堕粸(di菐n)銆備互绱潐閱囧拰闀锋槬鍫块钘ョ墿鐐轰唬琛ㄧ殑Tubulin鎶戝埗鍔�锛屽湪鑷ㄥ簥涓婂凡灞曠従(xi脿n)鍑洪’钁楃殑鎶楁湁绲插垎瑁傛椿鎬�銆傛牴鎿�(j霉)浣滅敤姗�(j墨)鍒剁殑涓嶅悓锛孴ubulin鎶戝埗鍔戝彲鍒嗙偤涓夊ぇ椤烇細寰鍘荤┅(w臎n)瀹氬姂锛圡icrotubule Destabilizing Agents, MDAs锛�銆佸井绠＄┅(w臎n)瀹氬姂锛圡icrotubule Stabilizing Agents, MSAs锛変互鍙婅繎骞翠締鐧�(f膩)鐝�(xi脿n)鐨勫井绠￠澏鍚戦檷瑙ｅ姂锛圡icrotubule-Targeting Degraders, MTDs锛�銆傜祼(ji茅)妲�(g貌u)鐢熺墿瀛�(xu茅)鐮旂┒宸叉垚鍔熻В鏋愪簡Tubulin浜岃仛楂斾笂鐨勫叓鍊�(g猫)涓昏绲�(ji茅)鍚堜綅榛�(di菐n)锛堝湒1锛�锛屽叾涓兜钃嬩簡绱潐閱�銆佺姘翠粰鍫�銆侀暦鏄ュ牽銆乴aulimalide銆佺編鐧荤礌銆丳ironetin銆丆evipabulin鍜孴odalam绲�(ji茅)鍚堜綅榛�(di菐n)銆傚叾涓�锛孧SAs閫氬父绲�(ji茅)鍚堜簬绱潐閱囧拰laulimalide浣嶉粸(di菐n)锛岄€氶亷绌�(w臎n)瀹氬井绠＄祼(ji茅)妲�(g貌u)鎶戝埗鍏惰В鑱�锛涜€孧DAs鍓囦富瑕侀澏鍚戠姘翠粰鍫裤€侀暦鏄ュ牽銆佺編鐧荤礌銆丳ironetin銆丆evipabulin鍜孴odalam浣嶉粸(di菐n)锛岄€氶亷骞叉摼寰鑱氬悎鎴栦績閫�(j矛n)鍏惰В鑱氱櫦(f膩)鎻綔鐢�銆侻TDs鍓囦富瑕佷綔鐢ㄤ簬Cevipabulin浣嶉粸(di菐n)锛屽悓鏅�(sh铆)涔熷寘鎷儴鍒嗛澏鍚戠姘翠粰鍫夸綅榛�(di菐n)鐨勯檷瑙ｅ姂锛岄€氶亷瑾樺皫(d菐o)Tubulin闄嶈В瀵�(sh铆)鐝�(xi脿n)鎶楄叓鐦ゆ晥鏋溿€傞€欎簺绲�(ji茅)鍚堜綅榛�(di菐n)鐨勭櫦(f膩)鐝�(xi脿n)鐐篢ubulin鎶戝埗鍔戠殑闁嬬櫦(f膩)鎻愪緵浜嗛噸瑕佺殑绲�(ji茅)妲�(g貌u)鍩虹(ch菙)锛屽悓鏅�(sh铆)涔熺偤閲濆皪涓嶅悓姗�(j墨)鍒剁殑鎶楃檶钘ョ墿瑷�(sh猫)瑷�(j矛)闁嬭緹浜嗘柊鐨勬柟鍚�銆�

Tubulin浜岃仛楂斾笂宸插牨(b脿o)閬撶殑8鍊�(g猫)鎶戝埗鍔戠祼(ji茅)鍚堜綅榛�(di菐n)

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鐒惰€�锛岀敱浜嶵M1鍚屾檪(sh铆)鑸囩姘翠粰鍫夸綅榛�(di菐n)鍜孴umabulin浣嶉粸(di菐n)绲�(ji茅)鍚堬紝閫欏叐鍊�(g猫)浣嶉粸(di菐n)涔嬮枔鐨勬經鍦ㄥ共鎿惧彲鑳藉奖闊垮皪TM1鍦═umabulin浣嶉粸(di菐n)鐨勭壒瀹氱敓鍖栧姛鑳界殑婧�(zh菙n)纰鸿В鏋�銆傜偤鍏嬫湇閫欎竴闄愬埗锛岀鐮斿湗(tu谩n)闅�(du矛)绮惧績瑷�(sh猫)瑷�(j矛)骞跺悎鎴愪簡鍖栧悎鐗㏕M2銆俆M2灏峊ubulin-RB3寰�(f霉)鍚堢墿鐨凾umabulin浣嶉粸(di菐n)鍏锋湁楂樺害閬告搰鎬э紝涓斾笉鑸囩姘翠粰鍫夸綅榛�(di菐n)鐧�(f膩)鐢熺浉浜掍綔鐢�銆�

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TM2鎶戝埗寰鐨勪綔鐢ㄦ(j墨)鍒�

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鍘熸枃閺堟帴锛�www.pnas.org/doi/10.1073/pnas.2424098122